Description

-Methyl-3-Trifluoromethylbenzyl Bromide is a versatile and high-value organobromine building block, essential for introducing the trifluoromethylbenzyl moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethyl group is a key pharmacophore for enhancing metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the research and development of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components.
• Fluorinated Compound Library: A crucial reagent for medicinal chemistry and discovery chemistry teams building diverse compound libraries for high-throughput screening.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules under cGMP conditions.

Basic Information

Product Name	-Methyl-3-Trifluoromethylbenzyl Bromide
CAS No.	68120-41-2
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	1-(Bromomethyl)-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)benzyl Bromide; α-Bromo-3-(trifluoromethyl)toluene; m-(Trifluoromethyl)benzyl Bromide; (3-Trifluoromethylphenyl)methyl Bromide; 3-Trifluoromethylbenzyl Bromide; 3-CF3-Benzyl Bromide; 1-Bromomethyl-3-trifluoromethylbenzene
EINECS	Contact for details

Quality Control

Our -Methyl-3-Trifluoromethylbenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.