Description

9-Hydroxycamptothecin is a potent, naturally derived alkaloid and a key intermediate in the synthesis of various topoisomerase I inhibitor anticancer agents. Its value lies in its role as a critical building block for developing novel chemotherapeutic drugs and for advanced pharmacological research. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potent camptothecin analogs and other topoisomerase I inhibitors used in cancer therapy.
• Oncology Research: Used as a reference standard and active compound in biochemical and cellular assays to study apoptosis, DNA damage, and cell cycle arrest.
• Drug Discovery & Development: Serves as a lead compound for the design, synthesis, and screening of new anticancer drug candidates with improved efficacy and reduced toxicity.
• Mechanistic Studies: Employed in research to elucidate the precise mechanism of action of topoisomerase I inhibitors and their interactions with DNA.
• Analytical Standard: Used in High-Performance Liquid Chromatography (HPLC) and other analytical methods for quality control and quantification of related compounds in pharmaceutical formulations.
• Bioconjugate Development: Investigated for use in creating antibody-drug conjugates (ADCs) or nanoparticle-based delivery systems to target cancer cells specifically.

Basic Information

Product Name	9-Hydroxycamptothecin
CAS No.	67656-30-8
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	9-HCPT; (S)-9-Hydroxycamptothecin; 9-Hydroxy-(S)-camptothecin; NSC 632788; 9-OH-CPT; Camptothecin, 9-hydroxy-; (19S)-9,10-Dihydroxy-20-oxocamptothecin; 9-Hydroxy-20(S)-camptothecin
EINECS	Contact for details

Quality Control

Our 9-Hydroxycamptothecin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, storage at 2-8°C is recommended. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.