Description

Esterastin is a potent and specific inhibitor of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which plays a critical role in intracellular cholesterol esterification. This compound is a valuable research tool for studying lipid metabolism, atherosclerosis, and related metabolic disorders. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular and metabolic disease research.

Application

• Biochemical Research: A key tool for investigating the ACAT enzyme pathway and its role in cholesterol homeostasis.
• Pharmaceutical R&D: Used in the discovery and development of novel therapeutic agents targeting atherosclerosis and hypercholesterolemia.
• Cell Biology Studies: Employed to modulate cholesterol esterification in cell culture models to study foam cell formation and lipid droplet biology.
• Metabolic Disorder Research: Applied in preclinical studies to understand the pathophysiology of diseases related to dysregulated lipid metabolism.
• Enzyme Inhibition Assays: Serves as a reference standard in high-throughput screening and in vitro assays for ACAT activity.

Basic Information

Product Name	Esterastin
CAS No.	67655-93-0
Molecular Formula	C31H40N2O5
Molecular Weight	520.66 g/mol
Synonyms	Esterastin; FR 145237; ACAT Inhibitor FR 145237; 3-Deoxy-3-[[(2S,3S)-2-[(2R,3R)-3-(1H-Indol-3-yl)-2-methyloxiran-2-yl]methyl]-3-methyloxiran-2-yl]carbonylamino]-D-erythro-hex-2-ulo-2,5-furanose; (2S,3S,4S,5R)-2-[[(2S,3S)-2-[(2R,3R)-3-(1H-Indol-3-yl)-2-methyloxiran-2-yl]methyl]-3-methyloxiran-2-yl]carbonylamino]-3,4,5-trihydroxy-2,6-dioxohexanal
EINECS	Contact for details

Quality Control

Our Esterastin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated upon opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.