Description

Thapsigargin is a potent and highly specific inhibitor of the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump, a key regulator of intracellular calcium homeostasis. This unique mechanism of action makes it an invaluable research tool for studying calcium signaling pathways, endoplasmic reticulum stress, and programmed cell death. It is essential for researchers and developers in the fields of cell biology, pharmacology, and oncology, serving as a critical compound for target validation and biochemical assay development.

Application

• Biomedical Research: A fundamental tool for inducing endoplasmic reticulum (ER) stress and studying the unfolded protein response (UPR) in cell culture models.
• Pharmacology & Drug Discovery: Used as a reference standard and positive control in high-throughput screening assays to identify novel SERCA modulators or cytoprotective agents.
• Cancer Research: Investigated for its ability to induce apoptosis in various cancer cell lines, aiding in the study of tumor biology and potential therapeutic pathways.
• Calcium Signaling Studies: Employed to disrupt intracellular calcium stores, enabling detailed research on calcium's role in cellular processes like muscle contraction, neurotransmission, and enzyme regulation.
• Biochemical Reagent: Used in the preparation of specialized buffers and kits for studying ATPase activity and calcium transport.

Basic Information

Product Name	Thapsigargin
CAS No.	67526-95-8
Molecular Formula	C34H50O12
Molecular Weight	650.76 g/mol
Synonyms	Thapsigargine; 6,7-Epoxy-3H,5H,11H,14H-oxireno[d,e]pyrano[4',3':4,5]furo[3,2-g]chromene-5,11,14(3H)-trione, 3-[(2R,3R,4S,5S,6R)-5-[(2S,3R,4R,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2-methyl-1-oxobut-2-en-1-yl)oxy]oxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-2,3,4,7,8,9,10,13-octahydro-2-hydroxy-4a,8a-dimethyl-11-(2-methylbut-2-enoyl)-, (2aR,3S,4S,4aR,5S,7S,8S,8aR,9S,10aR)-; SERCA Inhibitor; TG; Thapsigargin from Thapsia garganica
EINECS	Contact for details

Quality Control

Our Thapsigargin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.