Description

Thapsigargicin is a potent, cell-permeable sesquiterpene lactone natural product, a key structural analog of thapsigargin. This compound matters for its specific and potent inhibition of the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump, making it a critical tool for studying calcium signaling and endoplasmic reticulum stress in cellular systems. Researchers in pharmaceutical R&D, biochemistry, and molecular biology need it for investigating apoptosis pathways, developing novel cancer therapeutics, and as a reference standard in analytical studies.

Application

• Biochemical Research: As a potent and specific SERCA pump inhibitor for studying intracellular calcium homeostasis and signaling pathways.
• Pharmaceutical Development: A key reference compound and pharmacophore model for the design of novel anti-cancer agents targeting apoptosis.
• Cell Biology Studies: Used to induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in experimental models.
• Apoptosis Research: A tool compound for investigating programmed cell death mechanisms and screening for modulators.
• Natural Product Chemistry: Serves as an analytical standard for the identification and quantification of related sesquiterpene lactones.
• Signal Transduction Assays: Employed in high-throughput screening to identify compounds that affect calcium-dependent cellular processes.

Basic Information

Product Name	Thapsigargicin
CAS No.	67526-94-7
Molecular Formula	C34H50O12
Molecular Weight	650.8 g/mol
Synonyms	Thapsigargicin; 3,8-Dihydroxy-4,5,7,11b-tetramethyl-14-oxatetracyclo[7.5.1.0¹,¹⁰.0²,⁷]pentadec-11-en-6-one 8-acetate 3-(2-methylbutanoate); Thapsigargin analog; SERCA inhibitor analog; NSC 326023
EINECS	Contact for details

Quality Control

Our Thapsigargicin is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.