Description

Nitriloprostaglandin I2 is a synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is of significant interest in biochemical and pharmacological research for studying cardiovascular physiology and developing novel therapeutic agents. It is primarily utilized by researchers and development teams in the pharmaceutical, biotechnology, and life sciences sectors.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating vasodilation, platelet function, and vascular biology.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the synthesis and evaluation of new cardiovascular and anti-thrombotic drugs.
• Biochemical Assays: Employed in in vitro and cell-based assays to probe the role of the prostacyclin pathway and its receptors (IP receptor).
• Academic Research: A critical tool for universities and research institutions studying endothelial function, pulmonary hypertension, and ischemia-reperfusion injury models.
• Reference Standard Manufacturing: Supplied to analytical laboratories and manufacturers for use as a high-purity calibrant in quality control testing.

Basic Information

Product Name	Nitriloprostaglandin I2
CAS No.	67496-60-0
Molecular Formula	C₂₀H₂₉NO₄
Molecular Weight	347.45 g/mol
Synonyms	9-Deoxy-9α-nitrilo-PGI2; 9-Nitrilo-PGI2; Carbacyclin nitrile; Nitrilocarbacyclin; (5Z)-9-Deoxy-6,9α-nitrilo-δ⁵-PGF₁; Iloprost nitrile analog; Prostacyclin I2 nitrile analog
EINECS	Contact for details

Quality Control

Our Nitriloprostaglandin I2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.