Description

2-Chloro-4,5-Difluorobenzenesulfonyl Chloride is a versatile and highly reactive aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to act as a sulfonylation reagent, enabling the efficient introduction of the sulfonyl functional group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require the sulfonyl moiety for biological activity.
• Material Science: Building block for creating specialized polymers, dyes, and liquid crystals with unique properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzenesulfonyl Chloride
CAS No.	67475-58-5
Molecular Formula	C6H2Cl2F2O2S
Molecular Weight	247.04 g/mol
Synonyms	2-Chloro-4,5-Difluorobenzene-1-sulfonyl Chloride; 1-Chloro-2,3-Difluoro-4-(Chlorosulfonyl)Benzene; 4,5-Difluoro-2-Chlorobenzenesulfonyl Chloride; Benzenesulfonyl Chloride, 2-Chloro-4,5-Difluoro-; 2,3-Difluoro-6-Chlorobenzenesulfonyl Chloride; 67475-58-5; 2-Chloro-4,5-Difluorophenylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.