Description

Pent-4-Yne-1-Sulfonyl Chloride is a specialized organic building block featuring a terminal alkyne group and a reactive sulfonyl chloride moiety. This bifunctional nature makes it a valuable intermediate for synthesizing complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily utilized by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for constructing sulfonamide linkages and click chemistry applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring sulfonamide pharmacophores.
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) for bioconjugation and polymer functionalization.
• Polymer Modification: Used to introduce sulfonyl chloride functional groups into polymer chains for subsequent cross-linking or grafting reactions.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of new active ingredients with sulfonamide structures for crop protection.
• Material Science: Facilitates the surface functionalization of nanomaterials and the creation of advanced organic frameworks.

Basic Information

Item	Details
Product Name	Pent-4-Yne-1-Sulfonyl Chloride
CAS No.	67448-64-0
Molecular Formula	C5H7ClO2S
Molecular Weight	166.62 g/mol
Synonyms	4-Pentyn-1-sulfonyl chloride; 4-Pentynylsulfonyl chloride; 1-Butyn-4-ylsulfonyl chloride; Pent-4-yn-1-ylsulfonyl chloride; 4-Pentyne-1-sulfonyl chloride; 5-Chlorosulfonyl-1-pentyne
EINECS	Contact for details

Quality Control

Our Pent-4-Yne-1-Sulfonyl Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.