Description

18-Hydroxyprostaglandin E2 is a specialized prostaglandin analog, a key intermediate and reference standard in advanced biochemical research and pharmaceutical development. Its significance lies in its role as a potent bioactive lipid mediator, influencing critical physiological pathways related to inflammation, cellular proliferation, and vascular function. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on developing novel therapeutics and conducting mechanistic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Biochemical Research: Serves as a critical tool for studying prostaglandin receptors (EP receptors), signal transduction pathways, and the biochemistry of eicosanoids.
• Drug Discovery & Development: Acts as a key intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel anti-inflammatory or cytoprotective agents.
• Cell Biology Studies: Utilized in *in vitro* and *in vivo* models to investigate its effects on inflammation, pain perception, vascular tone, and gastric mucosa protection.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA) and LC-MS/MS methods for quantifying prostaglandin levels in biological samples.

Basic Information

Product Name	18-Hydroxyprostaglandin E2
CAS No.	67355-95-7
Molecular Formula	C₂₀H₃₄O₆
Molecular Weight	370.48 g/mol
Synonyms	18-Hydroxy PGE2; 18(R)-Hydroxyprostaglandin E2; 11α,15α-Dihydroxy-18-hydroxy-9-oxoprost-5-en-1-oic acid; 18-Hydroxy-PGE2; 18-OH-PGE2; Prostaglandin E2, 18-hydroxy-; (5Z,11α,13E,15S)-11,15,18-Trihydroxy-9-oxoprosta-5,13-dien-1-oic acid
EINECS	Contact for details

Quality Control

Our 18-Hydroxyprostaglandin E2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized; allow it to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.