Description

18-Hydroxyprostaglandin E1 is a specialized prostaglandin analog, a key intermediate in the synthesis of advanced pharmaceutical compounds. This high-purity biochemical is critical for research and development in targeted therapeutic areas, offering precise biological activity. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing novel drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex prostaglandin-based drug candidates.
• Biochemical Research: Used as a reference standard and active agent in studies investigating prostaglandin receptor activity, signaling pathways, and metabolic functions.
• Drug Discovery & Development: Employed in preclinical research for evaluating the efficacy and mechanism of action of new therapeutic entities targeting inflammation, cardiovascular, and renal systems.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories using techniques like HPLC and LC-MS.
• Fine Chemical Synthesis: Acts as a precursor for the custom synthesis of labeled compounds (e.g., deuterated, fluorinated) for advanced research applications.

Basic Information

Product Name	18-Hydroxyprostaglandin E1
CAS No.	67355-92-4
Molecular Formula	C₂₀H₃₄O₆
Molecular Weight	370.48 g/mol
Synonyms	18-Hydroxy PGE1; 18(R)-Hydroxyprostaglandin E1; 18-OH-PGE1; (5Z,11α,13E,15S)-11,15-Dihydroxy-18-hydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 18-Hydroxy-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; Prostaglandin E1, 18-hydroxy-
EINECS	Contact for details

Quality Control

Our 18-Hydroxyprostaglandin E1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets exacting standards for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.