Description

2-Hydroxyimino-4-Methylnitrosamino-1-(3-Pyridyl)-1-Butanone is a specialized nitrosamine derivative of significant interest in advanced chemical research and development. This compound serves as a critical intermediate or reference standard for analytical and synthetic chemistry applications, particularly in the study of nitrosamine formation and behavior. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and academic research institutions focused on impurity profiling, method development, and regulatory compliance.

Application

• Pharmaceutical Impurity Analysis: Used as a reference standard for the identification and quantification of nitrosamine impurities (e.g., NNK-related compounds) in active pharmaceutical ingredients (APIs) and drug products to meet stringent regulatory requirements (e.g., FDA, EMA).
• Analytical Method Development: Serves as a critical calibrant in developing and validating sensitive analytical methods, such as LC-MS/MS and HPLC, for trace-level nitrosamine detection.
• Chemical Research Intermediate: Acts as a key synthetic building block in organic chemistry research for the preparation of more complex nitrosamine derivatives or related heterocyclic compounds.
• Toxicological Studies: Employed in research settings to study the metabolism, carcinogenicity, and biochemical pathways of tobacco-specific nitrosamines (TSNAs).
• Quality Control & Assurance: Utilized by quality control laboratories in chemical and pharmaceutical manufacturing to ensure batch consistency and the absence of specific nitrosamine contaminants.

Basic Information

Product Name	2-Hydroxyimino-4-Methylnitrosamino-1-(3-Pyridyl)-1-Butanone
CAS No.	67351-31-9
Molecular Formula	C11H14N4O2
Molecular Weight	234.26 g/mol
Synonyms	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone oxime; NNK-oxime; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridinyl)-1-butanone oxime; 1-(3-Pyridyl)-4-(methylnitrosamino)-1-butanone oxime; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone oxime; 4-(N-Methyl-N-nitrosoamino)-1-(3-pyridyl)-1-butanone oxime; 4-(Methylnitrosamino)-1-(3-pyridyl)butan-1-one oxime
EINECS	Contact for details

Quality Control

Our 2-Hydroxyimino-4-Methylnitrosamino-1-(3-Pyridyl)-1-Butanone is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Research Grade)
Assay	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.