Description

Cyclobenzaprine n--D-Glucuronide is a major, phase II metabolite of the centrally-acting muscle relaxant cyclobenzaprine. This compound is of critical importance for pharmaceutical research and development, specifically in the areas of drug metabolism and pharmacokinetics (DMPK) studies. It serves as a vital reference standard for analytical method development, bioanalytical testing, and regulatory compliance. Researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors require this high-purity metabolite to ensure accurate quantification and understanding of the parent drug's metabolic profile.

Application

• Pharmaceutical Reference Standard: Primary use as an authenticated standard for qualitative and quantitative analysis in drug development and quality control.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo DMPK studies to map the metabolic pathways of Cyclobenzaprine.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS, HPLC, or UPLC methods for metabolite detection in biological matrices.
• Toxicology and Safety Assessment: Supports studies investigating the safety and toxicity profile of drug metabolites.
• Impurity Characterization: Aids in the identification and control of potential glucuronide-related impurities in active pharmaceutical ingredient (API) batches.
• Clinical Research: Used as a calibrator or control in assays measuring metabolite levels during clinical trials.

Basic Information

Product Name	Cyclobenzaprine n--D-Glucuronide
CAS No.	67324-97-4
Molecular Formula	C₂₅H₂₈NO₇
Molecular Weight	454.50 g/mol
Synonyms	Cyclobenzaprine N-Glucuronide; Cyclobenzaprine Glucuronide; 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Glucuronide; Fexmid Metabolite (Glucuronide); Amrix Metabolite; Cyclobenzaprine Major Metabolite; 1-N-Glucuronyl-cyclobenzaprine
EINECS	Contact for details

Quality Control

Our Cyclobenzaprine n--D-Glucuronide is manufactured under strict quality systems suitable for research and analytical applications. Each batch is characterized and tested to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, NMR, and MS confirmation. Our quality commitment ensures reliability for your most demanding analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and must be kept dry. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Water Content (KF)	≤5.0% w/w
Solubility	Soluble in Methanol, DMSO; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.