Description

Tn Antigen CAS NO 67262-86-6 is a crucial carbohydrate antigen, specifically the O-linked N-acetylgalactosamine (GalNAc) α-linked to serine or threonine residues of a protein. This compound is of significant value in glycobiology and immunology research as a key tumor-associated antigen. It is primarily needed by biotechnology, pharmaceutical, and diagnostic sectors for applications in cancer research, vaccine development, and the production of specific antibodies and detection kits.

Application

• Biomedical Research: Critical reagent for studying Tn antigen expression in cancer biology, tumor immunology, and glycosylation disorders.
• Diagnostic Development: Used as a coating antigen or standard in immunoassays (ELISA) and lateral flow tests for detecting anti-Tn antibodies.
• Vaccine Research: Serves as a target epitope in the development of cancer vaccines and immunotherapies aimed at eliciting an immune response against Tn-positive tumors.
• Glycoprotein Synthesis: Employed as a building block in the chemical and enzymatic synthesis of Tn-glycoproteins and glycopeptides for structural and functional studies.
• Antibody Production & Screening: Essential for the generation, purification, and characterization of monoclonal and polyclonal antibodies specific to the Tn epitope.
• Cell Biology Studies: Used to probe lectin binding and cell surface interactions, helping to understand cell adhesion and signaling mechanisms.

Basic Information

Product Name	Tn Antigen
CAS No.	67262-86-6
Molecular Formula	C8H15NO6
Molecular Weight	221.21 g/mol
Synonyms	GalNAc-α-Ser/Thr; O-(N-Acetyl-α-D-galactosaminyl)-L-serine; O-(N-Acetyl-α-D-galactosaminyl)-L-threonine; Tn Antigen (GalNAcα1-O-Ser/Thr); N-Acetyl-α-D-galactosaminyl-O-serine; N-Acetyl-α-D-galactosaminyl-O-threonine; α-GalNAc-Ser; α-GalNAc-Thr
EINECS	Contact for details

Quality Control

Our Tn Antigen is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.