Description

Mono-6-o-(p-Toluenesulfonyl)-β-Cyclodextrin CAS NO 67217-55-4 is a key functionalized derivative of β-cyclodextrin, where a single tosyl group is selectively introduced at the primary hydroxyl position, creating a versatile intermediate for further chemical synthesis. This precise functionalization is critical for developing advanced materials and pharmaceutical agents with tailored properties, such as enhanced solubility, targeted delivery, or specific molecular recognition. It is an essential building block for researchers and manufacturers in pharmaceutical development, supramolecular chemistry, and advanced material science who require high-purity, well-characterized intermediates.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor for synthesizing more complex cyclodextrin derivatives used in drug formulation, solubility enhancement, and controlled release systems.
• Supramolecular Chemistry Research: Used as a building block to create novel host-guest complexes, molecular machines, and sensors due to its reactive tosyl handle for further conjugation.
• Chiral Separation Media: Acts as a starting material for manufacturing stationary phases in chromatography columns designed for enantiomer separation.
• Polymer & Material Science: Employed to synthesize cyclodextrin-based polymers, hydrogels, and functional surfaces for catalysis, filtration, or encapsulation.
• Bioconjugation & Labeling: The reactive sulfonate ester group facilitates the attachment of biomolecules, dyes, or other functional groups to the cyclodextrin scaffold.
• Catalyst & Ligand Synthesis: Used to develop sophisticated ligands and catalysts for asymmetric synthesis and green chemistry applications.

Basic Information

Product Name	Mono-6-o-(p-Toluenesulfonyl)-β-Cyclodextrin
CAS No.	67217-55-4
Molecular Formula	C55H84O42S
Molecular Weight	1369.29 g/mol
Synonyms	6-O-(p-Tolylsulfonyl)-β-cyclodextrin; 6-O-Tosyl-β-cyclodextrin; β-Cyclodextrin 6-mono-p-toluenesulfonate; Mono-6-O-tosyl-β-cyclodextrin; 6-Mono-O-(tosyl)-β-cyclodextrin; 6-O-(4-Methylbenzenesulfonyl)-β-cyclodextrin; β-CD-6-OTs; Heptakis[6-O-(p-toluenesulfonyl)]-β-cyclodextrin (misnomer for mono-substituted, but sometimes listed)
EINECS	Contact for details

Quality Control

Our Mono-6-o-(p-Toluenesulfonyl)-β-Cyclodextrin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and structural confirmation by NMR and MS, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.