Description

(+/-)-U-50488 Hydrochloride is a selective κ-opioid receptor (KOR) agonist, a key pharmacological tool compound for neuroscience and pain management research. Its primary value lies in its ability to help researchers study the complex signaling pathways of the κ-opioid system without the confounding effects of mu-opioid receptor activation. This makes it essential for pharmaceutical R&D teams, academic institutions, and contract research organizations (CROs) focused on developing novel analgesics, understanding addiction mechanisms, and exploring neuropsychiatric disorders.

Application

• Neuroscience Research: A critical tool for studying the physiological and behavioral effects of κ-opioid receptor activation in the central nervous system.
• Analgesic Drug Discovery: Used in preclinical studies to investigate KOR-mediated pain relief pathways and to screen for new, non-addictive pain therapeutics.
• Psychopharmacology Studies: Employed in research models for depression, anxiety, and stress-related disorders due to the KOR's role in dysphoria and mood regulation.
• Addiction Research: Serves as a reference compound to explore the KOR's influence on reward circuitry and its potential role in modulating substance abuse.
• Biochemical Assay Development: Used as a standard or control in receptor binding assays (e.g., radioligand binding) and functional cellular assays to validate test systems.
• Academic & Institutional Research: A standard reagent for graduate and post-doctoral studies in pharmacology, neurobiology, and medicinal chemistry.

Basic Information

Product Name	(+/-)-U-50488 Hydrochloride
CAS No.	67198-17-8
Molecular Formula	C15H22ClNO2 • HCl
Molecular Weight	320.26 g/mol
Synonyms	U-50488 Hydrochloride; (±)-U-50488 Hydrochloride; trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide Hydrochloride; U-50488H; U50488 Hydrochloride; U-50,488 Hydrochloride; 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide Hydrochloride (racemic mixture)
EINECS	Contact for details

Quality Control

Our (+/-)-U-50488 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.