Description

(Difluoromethoxy)Benzaldehyde is a versatile aromatic aldehyde building block distinguished by its difluoromethoxy substituent. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical molecules, where the fluorine atoms can significantly modulate biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex target structures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances lipophilicity and biological efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorine-containing organic electronic materials for displays and lighting.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, improving chemical resistance and thermal stability.
• Organic Synthesis & Catalysis Research: A valuable substrate in academic and industrial research for developing new fluorination methodologies and cross-coupling reactions.
• Flavor & Fragrance Intermediate: Can be utilized in the synthesis of complex aromatic compounds for specialty fragrance applications.

Basic Information

Product Name	(Difluoromethoxy)Benzaldehyde
CAS No.	66988-93-0
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	Benzaldehyde, (difluoromethoxy)-; α,α-Difluoroanisaldehyde; 2,2-Difluoro-2-phenoxymethanal; (Difluoromethoxy)benzene-1-carbaldehyde; 4-(Difluoromethoxy)benzaldehyde (isomer); DFMB; Difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our (Difluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.