Description

7-Hydroxy Coumarin Glucuronide is a crucial glucuronide conjugate metabolite of the bioactive compound umbelliferone. This high-purity reference standard is essential for analytical and research applications requiring precise quantification and metabolic pathway studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug metabolism, pharmacokinetics (PK/ADME), and biomarker analysis.

Application

• Pharmacokinetic and ADME Studies: Serves as a critical analytical standard for quantifying the glucuronidation metabolite of umbelliferone (7-hydroxycoumarin) in biological matrices like plasma, urine, and tissue homogenates.
• Enzyme Activity Assays: Used as a substrate or reference compound in assays to study the activity of UDP-glucuronosyltransferase (UGT) enzymes, which are vital for Phase II drug metabolism.
• Biomarker Research: Acts as a reference standard in the development and validation of LC-MS/MS or HPLC-UV methods for detecting specific metabolic biomarkers in clinical or preclinical research.
• Drug Development Reference: Provides a certified standard for quality control and method validation in pharmaceutical development, ensuring accurate metabolite profiling for regulatory submissions.
• Toxicological Studies: Employed in research investigating detoxification pathways and the metabolic fate of coumarin derivatives and related compounds.

Basic Information

Product Name	7-Hydroxy Coumarin Glucuronide
CAS No.	66695-14-5
Molecular Formula	C15H16O9
Molecular Weight	340.28 g/mol
Synonyms	7-Hydroxycoumarin Glucuronide; Umbelliferone Glucuronide; 7-Hydroxy-2H-1-benzopyran-2-one β-D-Glucopyranosiduronic Acid; 7-Hydroxycoumarin β-D-Glucuronide; Hymecromone Metabolite; 7-HC-G; Skimmetin Glucuronide; 7-Hydroxy-2-oxo-2H-chromen-7-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Coumarin Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.