Description

Ansamitocin p-3 is a potent ansamycin-class antitumor antibiotic isolated from microbial fermentation. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for antibody-drug conjugate (ADC) therapeutics. It is essential for researchers and manufacturers in the oncology and biopharmaceutical sectors who require high-purity, well-characterized bioactive compounds for drug discovery and quality control processes.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in the development of targeted cancer therapies.
• Pharmaceutical Reference Standard: Used for quality control, method validation, and regulatory compliance in API and finished drug product manufacturing.
• Oncology Research: Employed in in vitro and in vivo studies to investigate mechanisms of action, efficacy, and toxicity of maytansinoid derivatives.
• Biochemical Tool Compound: Utilized to study tubulin polymerization inhibition and its effects on cellular mitosis.
• Process Development: Acts as a key intermediate and benchmark in the synthetic and fermentation process development for maytansinoid-based drugs.

Basic Information

Product Name	Ansamitocin p-3
CAS No.	66584-72-3
Molecular Formula	C32H43ClN2O9
Molecular Weight	635.15 g/mol
Synonyms	Ansamitocin P-3; Ansamitocin P3; Antibiotic C 15003 P 3; Maytansinol, N2-deacetyl-N2-(3-mercapto-1-oxopropyl)-, (2S)-; DM1; Mertansine; NSC 332598; (2S)-N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)maytansine
EINECS	Contact for details

Quality Control

Our Ansamitocin p-3 is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (IR, MS) to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.