Description

n-(Phosphonoacetyl)-L-Aspartic Acid 1,4-Disodium Salt is a high-purity, water-soluble derivative of aspartic acid, designed for advanced biochemical and pharmaceutical research. This compound serves as a critical intermediate and a potent inhibitor of key enzymatic pathways, offering significant value in the development of targeted therapeutics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in enzyme inhibition studies and the synthesis of novel drug candidates.

Application

• Enzyme Inhibition Studies: Acts as a potent and specific inhibitor of aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine biosynthesis, making it invaluable for biochemical research and pathway analysis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of nucleotide analogs and other chemotherapeutic agents targeting cancer cell proliferation.
• Biochemical Research Reagent: Used in high-throughput screening assays and kinetic studies to understand enzyme mechanisms and identify potential drug targets.
• Academic & Industrial R&D: Essential for universities, contract research organizations (CROs), and pharmaceutical R&D departments investigating metabolic disorders and developing new therapeutic strategies.

Basic Information

Product Name	n-(Phosphonoacetyl)-L-Aspartic Acid 1,4-Disodium Salt
CAS No.	66569-27-5
Molecular Formula	C6H7NNa2O8P
Molecular Weight	305.07 g/mol
Synonyms	PALA Disodium Salt; N-Phosphonacetyl-L-aspartate Disodium Salt; L-Aspartic Acid, N-(phosphonoacetyl)-, Disodium Salt; PALA; (2S)-2-[[(Carboxymethyl)(hydroxy)phosphoryl]amino]butanedioic Acid Disodium Salt; ATase Inhibitor; Aspartate Transcarbamoylase Inhibitor; NSC 224131
EINECS	Contact for details

Quality Control

Our n-(Phosphonoacetyl)-L-Aspartic Acid 1,4-Disodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider using a desiccator or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
pH (5% Solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.