Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(3-Methyl-1-Oxobutyl)- is a potent cytotoxic agent belonging to the ansamycin class of natural products. This compound is of significant interest for its role as a key payload in the development of antibody-drug conjugates (ADCs), a cutting-edge class of targeted cancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and advanced manufacturers specializing in oncology drug development and production.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the highly potent cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel anti-cancer agents.
• Bioconjugation Chemistry: A critical intermediate for scientists developing new linker technologies and conjugation methodologies for targeted drug delivery systems.
• Mechanistic Studies: Employed in biochemical and cellular assays to study microtubule inhibition and apoptosis induction in cancer cells.
• Process Development & Scale-Up: Sourced by manufacturers for the development and GMP production of ADC-based pharmaceuticals.

Basic Information

Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(3-Methyl-1-Oxobutyl)-
CAS No.	66547-10-2
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	DM1; Mertansine; Ansamitocin P-3; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Maytansinoid DM1; NSC-330507; (2S)-2-[[(2S,3R,4S,5S,6R)-5-[[(2R,3S,4S,6S)-6-[[(2S,3S)-3-[[(2R)-1-[[(2S)-1-[[(2S,3S)-3-[[(2S)-3-Chloro-2-hydroxy-1-oxopropyl]amino]-2-methyl-1-oxopentan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-methyl-1-oxobutan-4-yl]carbamoyl]-4-methoxy-2-methyloxan-3-yl]oxy]-4-dimethoxy-6-methyloxan-3-yl]oxy]-3-methoxy-2-methylpropanoic acid
EINECS	Contact for details

Quality Control

Our Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(3-Methyl-1-Oxobutyl)- is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.