Description

Ansamitocin P-3 is a potent ansamycin-class antitumor antibiotic originally isolated from *Actinosynnema pretiosum*. This compound is a critical intermediate and reference standard in the development of antibody-drug conjugates (ADCs), particularly those targeting microtubule dynamics. It is essential for pharmaceutical R&D, process development, and quality control laboratories focused on next-generation oncology therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in ADCs, where it is conjugated to monoclonal antibodies for targeted cancer therapy.
• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control of ADC drug substances and products.
• Biochemical Research: A tool compound for studying microtubule inhibition, apoptosis induction, and the mechanism of action of maytansinoid derivatives.
• Process Development & Scale-Up: Employed as a key intermediate in the synthetic and biosynthetic pathways for producing clinical-grade ADC payloads.
• Oncology Drug Discovery: Evaluated in preclinical studies for its antitumor efficacy against various cancer cell lines.

Basic Information

Product Name	Ansamitocin P-3
CAS No.	66547-09-9
Molecular Formula	C32H43ClN2O9
Molecular Weight	635.15 g/mol
Synonyms	Ansamitocin P3; Antibiotic C 15003 P3; Maytansinol, 4,5-Deoxy-4,5-didehydro-19-demethyl-19-oxo-3-[(2E)-1-oxo-3-(trimethylsilyl)-2-propen-1-yl]-, 3-ester with N2-[3-(Acetyloxy)-2-methyl-1-oxopropyl]-N1-[(3R,4S,5S)-3-methoxy-1-oxo-5-methyl-4-(methylamino)heptyl]-L-alaninamide, (2R)-; DM1; mertansine; NSC-332598
EINECS	Contact for details

Quality Control

Our Ansamitocin P-3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for pharmaceutical development and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting full compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed under dry, oxygen-free conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.