Description

4-Hydroxybestatin is a potent and selective inhibitor of aminopeptidase N (APN), also known as CD13, which plays a critical role in tumor angiogenesis and metastasis. This compound is a key intermediate and research tool for developing novel therapeutics targeting cancer and inflammatory diseases. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on oncology, immunology, and protease inhibitor discovery.

Application

• Pharmaceutical Research & Development: As a critical intermediate in the synthesis of novel aminopeptidase N (APN/CD13) inhibitors for cancer therapy.
• Biochemical Assay Standard: Used as a reference standard in enzymatic assays to study APN activity and inhibition kinetics.
• Oncology Drug Discovery: A key tool compound for evaluating anti-angiogenic and anti-metastatic effects in preclinical cancer models.
• Academic Research: Employed in university and institutional labs to investigate the role of CD13 in immunology, inflammation, and cell signaling pathways.
• Peptidase Inhibitor Studies: Serves as a selective inhibitor to distinguish APN activity from other metalloproteases in complex biological systems.

Basic Information

Product Name	4-Hydroxybestatin
CAS No.	66413-44-3
Molecular Formula	C₁₆H₂₂N₂O₅
Molecular Weight	322.36 g/mol
Synonyms	(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl-L-leucine; Hydroxybestatin; APN Inhibitor; CD13 Inhibitor; (2S,3R)-AHPA-L-Leu; Bestatin Hydroxy Analog; N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
EINECS	Contact for details

Quality Control

Our 4-Hydroxybestatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.