Description

Apogossypol is a polyphenolic compound derived from cottonseed, known for its potent biological activity. This compound is of significant interest in pharmaceutical research and development due to its role as a specific inhibitor of Bcl-2 family proteins, which are key regulators of apoptosis. It is primarily utilized by researchers and manufacturers in the life sciences sector for oncology studies, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of anticancer therapeutics.
• Oncology Studies: Used as a biochemical tool to study apoptosis mechanisms and validate Bcl-2 family protein targets in various cancer cell lines.
• Preclinical Drug Discovery: Employed in high-throughput screening assays and in vitro/vivo studies to evaluate the efficacy and toxicity of apoptosis-inducing agents.
• Academic Research: Utilized in university and institutional laboratories for fundamental research on cell death pathways and signal transduction.
• Biochemical Reagent: Acts as a specific inhibitor in enzymatic and protein-binding assays to elucidate biological pathways.

Basic Information

Product Name	Apogossypol
CAS No.	66389-74-0
Molecular Formula	C30H30O8
Molecular Weight	518.56 g/mol
Synonyms	(-)-Apogossypol; BL-193; NSC 736630; AT-101; 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; Gossypol derivative; Bcl-2 inhibitor AT-101
EINECS	Contact for details

Quality Control

Our Apogossypol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. The product should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.