Description

3',4'-Anhydro Vincristine is a key synthetic intermediate and derivative of the potent antineoplastic alkaloid vincristine. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis and structural modification of complex vinca alkaloids. It serves as a critical building block for medicinal chemists and researchers focused on oncology drug discovery and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of vincristine and related vinca alkaloid derivatives for cancer therapy.
• Medicinal Chemistry Research: A crucial precursor for structure-activity relationship (SAR) studies to develop new anticancer compounds with improved efficacy or reduced toxicity.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for the identification and quantification of vinca alkaloids.
• Biochemical Research: Employed in studies investigating the mechanism of action of microtubule-targeting agents and their interaction with tubulin.
• Process Development: Utilized in the development and optimization of scalable synthetic routes for complex natural product-derived pharmaceuticals.

Basic Information

Product Name	3',4'-Anhydro Vincristine
CAS No.	66337-94-8
Molecular Formula	C46H56N4O9
Molecular Weight	808.97 g/mol
Synonyms	3',4'-Anhydrovincristine; 22-Oxovincaleukoblastine, 3',4'-anhydro-; Leurocristine, 3',4'-anhydro-; Anhydrovincristine; Vincristine, 3',4'-anhydro-; 3',4'-Dehydrovincristine; (3aR,4R,5S,5aR,10bR,13aR)-4-(Acetyloxy)-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid methyl ester
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Quality Control

Our 3',4'-Anhydro Vincristine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.