Description

Benzyloxycarbonylleucyl-Hydroxamate CAS NO 66179-55-3 is a protected peptide derivative and hydroxamic acid compound, serving as a critical building block and enzyme inhibitor precursor in advanced organic synthesis. Its value lies in its dual functionality, offering a protected amino acid moiety alongside a hydroxamate group that is pivotal for chelating metal ions, particularly in the development of protease inhibitors. This makes it an essential intermediate for researchers and manufacturers in the pharmaceutical and biochemical research sectors, where it is used to develop novel therapeutic agents and study enzyme mechanisms.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of matrix metalloproteinase (MMP) inhibitors and other hydroxamate-based drug candidates.
• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic studies, particularly for zinc-dependent hydrolases like aminopeptidases.
• Peptide Synthesis: Serves as a protected leucine derivative in solid-phase and solution-phase peptide chemistry.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting various diseases.
• Chemical Biology Probes: Utilized in the development of activity-based probes (ABPs) to label and study specific enzyme families in complex biological systems.

Basic Information

Product Name	Benzyloxycarbonylleucyl-Hydroxamate
CAS No.	66179-55-3
Molecular Formula	C14H20N2O5
Molecular Weight	296.32 g/mol
Synonyms	Z-Leu-NHOH; Cbz-Leu-NHOH; N-Carbobenzoxy-L-leucine hydroxamate; Benzyloxycarbonyl-L-leucylhydroxamic acid; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methyl-N-hydroxypentanamide; Z-L-Leucine hydroxamate; N-Hydroxy-N-[(phenylmethoxy)carbonyl]-L-leucinamide; Carbobenzyloxy-L-leucine hydroxamic acid
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonylleucyl-Hydroxamate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity and chiral purity verification, to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.