Description

Nefopam n-Oxide is a key pharmaceutical intermediate and metabolite of the centrally-acting analgesic, nefopam hydrochloride. This compound is of significant interest for research and development in the field of pain management and drug metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers specializing in active pharmaceutical ingredients (APIs) and high-purity reference standards.

Application

• Pharmaceutical Intermediate: Critical synthesis precursor in the production of nefopam-based analgesic drugs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify nefopam metabolites in biological matrices.
• Pharmacological Research: Employed in preclinical and clinical studies to investigate the metabolic pathways, pharmacokinetics, and efficacy of nefopam.
• Quality Control & Impurity Profiling: Serves as a known impurity or reference compound in the HPLC/GC analysis for the quality assurance of nefopam API batches.
• Academic Research: Used in university and institutional labs for studies in medicinal chemistry, neuropharmacology, and analytical method development.

Basic Information

Product Name	Nefopam n-Oxide
CAS No.	66091-32-5
Molecular Formula	C17H19NO2
Molecular Weight	269.34 g/mol
Synonyms	Nefopam N-Oxide; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine 5-Oxide; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine 5-Oxide; Nefopam Oxide; Nefopam Metabolite; Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, 5-oxide
EINECS	Contact for details

Quality Control

Our Nefopam n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material should be kept under inert conditions if long-term stability is required.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.