Description

Tunicamycin A1 Homolog CAS NO 66081-37-6 is a specific homolog of the tunicamycin complex, a well-characterized nucleoside antibiotic that potently inhibits N-linked glycosylation. This compound is a critical research tool for studying protein glycosylation pathways, endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in eukaryotic cells. It is essential for researchers and developers in life sciences, particularly in molecular biology, cell biology, and pharmaceutical discovery programs targeting cancer and metabolic diseases.

Application

• Biochemical Research: Used as a selective inhibitor to study N-linked protein glycosylation, glycoprotein synthesis, and quality control mechanisms in the ER.
• Cell Biology Studies: Induces ER stress and activates the UPR pathway, making it vital for research on cellular stress responses, apoptosis, and autophagy.
• Cancer Research: Investigated for its effects on cancer cell proliferation, metastasis, and tumor microenvironment, as glycosylation is often altered in malignancies.
• Antiviral Research: Explored for its potential to inhibit the glycosylation of viral envelope proteins, which is crucial for the infectivity of many viruses.
• Drug Discovery: Serves as a reference compound and a tool for validating targets and screening compounds in drug development pipelines focused on glycosylation-related diseases.
• Academic & Pharmaceutical R&D: A standard reagent in laboratories for fundamental research into glycobiology, signal transduction, and the development of novel therapeutic strategies.

Basic Information

Product Name	Tunicamycin A1 Homolog
CAS No.	66081-37-6
Molecular Formula	C39H64N4O16
Molecular Weight	844.94 g/mol
Synonyms	Tunicamycin A1; Antibiotic Tunicamycin A1; Tunicamycin I; Tunicamycin Complex Homolog A1; Streptomyces lysosuperificus antibiotic; Nucleoside antibiotic inhibiting peptidoglycan synthesis; UDP-HexNAc:polyprenol-P HexNAc-1-P transferase inhibitor; Glycosylation Inhibitor I
EINECS	Contact for details

Quality Control

Our Tunicamycin A1 Homolog is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to high-purity standards suitable for life science research, with quality systems designed to meet the rigorous demands of pharmaceutical and academic R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into single-use vials to avoid repeated freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Inhibits protein glycosylation in cell-based assays
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.