Description

N'-Nitro-D-Arginine is a specialized, non-proteinogenic derivative of the amino acid arginine, where the guanidino group is modified with a nitro substituent. This compound serves as a critical chiral building block and a selective inhibitor in advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical development laboratories focused on nitric oxide synthase (NOS) studies, peptide synthesis, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a selective inhibitor for studying the structure, function, and inhibition mechanisms of nitric oxide synthase (NOS) isoforms.
• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of complex peptide-based drugs and potential therapeutic candidates.
• Enzyme Kinetics Studies: Used to investigate enzyme-substrate interactions and inhibition constants in metabolic pathway research.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic Research: A vital tool in university and institutional labs for proteomics, signal transduction, and cardiovascular research projects.

Basic Information

Product Name	N'-Nitro-D-Arginine
CAS No.	66036-77-9
Molecular Formula	C6H13N5O4
Molecular Weight	219.20 g/mol
Synonyms	D-NG-Nitroarginine; (R)-2-Amino-5-[(nitroamino)imino]pentanoic acid; Nω-Nitro-D-arginine; D-NNA; NG-Nitro-D-arginine; D-Nitroarginine; (R)-N5-(Iminonitroamino)-2-aminopentanoic Acid; H-D-Arg(NO2)-OH
EINECS	Contact for details

Quality Control

Our N'-Nitro-D-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.