Description

(-)-Bicuculline Methbromide CAS NO 66016-70-4 is a high-purity, potent, and selective antagonist of the GABAA receptor. This compound is a critical research tool in neuroscience and pharmacology for studying inhibitory neurotransmission. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neurological disorders, receptor characterization, and drug discovery.

Application

• Neuroscience Research: A standard pharmacological tool for blocking GABAA receptor-mediated inhibitory postsynaptic currents (IPSCs) in electrophysiology studies.
• Pharmacological Studies: Used to investigate the role of GABAergic inhibition in various brain functions, including seizure activity, anxiety, and sedation.
• Drug Discovery & Screening: Employed in high-throughput screening assays to identify novel GABAA receptor modulators or potential anticonvulsant drugs.
• Receptor Characterization: Essential for defining receptor subtypes and understanding the structure-activity relationships of the GABAA receptor complex.
• Biochemical Assays: Used in radioligand binding studies to determine receptor density and affinity in tissue preparations.
• Toxicology Research: Applied in studies examining the mechanisms of action of convulsants and neurotoxins.

Basic Information

Product Name	(-)-Bicuculline Methbromide
CAS No.	66016-70-4
Molecular Formula	C21H20BrNO6
Molecular Weight	462.29 g/mol
Synonyms	(-)-Bicuculline Methobromide; Bicuculline Methobromide; (S)-(-)-Bicuculline Methobromide; NSC 224994; (1S)-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one methobromide; GABAA Receptor Antagonist (selective)
EINECS	Contact for details

Quality Control

Our (-)-Bicuculline Methbromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous requirements of the research and pharmaceutical development sectors.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.