Description

Methylglyoxal Bis(Butylamidinohydrazone) is a specialized chemical compound with significant utility in biochemical and pharmaceutical research. Its primary value lies in its function as a potent and selective inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the polyamine biosynthesis pathway. This makes it an essential research tool for scientists studying cell growth, proliferation, and the development of therapeutic agents targeting conditions like cancer and parasitic diseases. The compound is primarily sought by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in metabolic pathway analysis and drug discovery.

Application

• Biochemical Research: As a specific inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC) to study polyamine metabolism and its role in cellular processes.
• Antiproliferative Studies: Used in in vitro and in vivo research to investigate the inhibition of tumor cell growth and proliferation.
• Parasitology Research: Investigation of potential therapeutic applications against parasitic infections (e.g., trypanosomiasis) where polyamine biosynthesis is a target.
• Enzyme Kinetics: A critical tool for characterizing the activity and inhibition kinetics of the AdoMetDC enzyme.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery and development of novel chemotherapeutic agents.
• Academic Research: Fundamental studies in molecular biology, biochemistry, and cell signaling pathways related to polyamines.

Basic Information

Product Name	Methylglyoxal Bis(Butylamidinohydrazone)
CAS No.	66002-88-8
Molecular Formula	C12H26N6
Molecular Weight	254.38 g/mol
Synonyms	MGBG; Methyl-GAG; Methylglyoxal Bis(guanylhydrazone); Mitoguazone; NSC-32946; Methylglyoxal Bis(amidinohydrazone); 1,1'-[(Methylethanediylidene)dinitrilo]diguanidine; Methylglyoxal bis(butylamidinohydrazone) dihydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Methylglyoxal Bis(Butylamidinohydrazone) is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.