Description

2-Fluoro-3-Trifluoromethylpyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, makes it an essential intermediate for creating compounds with tailored electronic and physicochemical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated motifs to enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can significantly improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis, including those for cross-coupling reactions, due to the electron-withdrawing nature of its substituents.
• Material Science Research: Employed in the creation of functional materials, such as liquid crystals, organic semiconductors, and polymers, where fluorination adjusts electronic properties and stability.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Fluoro-3-Trifluoromethylpyridine
CAS No.	65753-52-8
Molecular Formula	C6H3F4N
Molecular Weight	165.09 g/mol
Synonyms	2-Fluoro-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-fluoropyridine; 2-Fluoro-α,α,α-trifluoro-3-picoline; Pyridine, 2-fluoro-3-(trifluoromethyl)-; 65753-52-8
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Trifluoromethylpyridine is manufactured and tested under a strict quality management system. We ensure the product meets the high-purity standards required for sensitive synthetic applications. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.