Description

(8S)-2-Bromo α-Ergocryptine CAS NO 65700-36-9 is a brominated derivative of the ergot alkaloid α-ergocryptine, characterized by its specific stereochemistry at the 8-position. This compound is a critical intermediate in advanced pharmaceutical research and development, particularly for the synthesis of novel dopamine receptor agonists and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuropharmacology, endocrinology, and the development of treatments for conditions like Parkinson's disease and hyperprolactinemia.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced dopamine D2 receptor agonists and other therapeutic agents.
• Neurological Research: Used in preclinical studies to investigate dopaminergic pathways and receptor binding affinities.
• Endocrine Disorder Studies: Employed in research targeting prolactin secretion and related hormonal imbalances.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities.
• Biochemical Research: Used in studies exploring the mechanism of action of ergot alkaloid derivatives.

Basic Information

Product Name	(8S)-2-Bromo α-Ergocryptine
CAS No.	65700-36-9
Molecular Formula	C₃₂H₄₁BrN₅O₅
Molecular Weight	655.60 g/mol
Synonyms	2-Bromo-α-ergocryptine; 2-Bromo-α-ergokryptin; (8S)-2-Bromoergocryptine; Bromocriptine Impurity; 2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'α-(2-methylpropyl)ergotaman-3',6',18-trione; 2-Bromocryptine
EINECS	Contact for details

Quality Control

Our (8S)-2-Bromo α-Ergocryptine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.