Description

Tyrphostin Ag 1024 is a potent and selective small-molecule inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases. This compound is a critical research tool for studying cellular signaling pathways related to growth, metabolism, and oncogenesis. It is primarily utilized by researchers and scientists in the fields of biochemistry, molecular biology, and oncology for in vitro and in vivo studies.

Application

• Biomedical Research: Used as a selective inhibitor to study the role of IGF-1R and IR signaling in cell proliferation, differentiation, and apoptosis.
• Cancer Research: Investigated for its potential to inhibit tumor growth and metastasis in various cancer cell lines and animal models.
• Metabolic Disorder Studies: Applied in research exploring insulin resistance, diabetes, and related metabolic pathways.
• Signal Transduction Analysis: A key reagent for dissecting complex tyrosine kinase-mediated signaling networks.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the development of novel targeted cancer therapeutics.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical studies in university laboratories and pharmaceutical R&D departments.

Basic Information

Product Name	Tyrphostin Ag 1024
CAS No.	65678-07-1
Molecular Formula	C₁₇H₁₄N₄O₃
Molecular Weight	322.32 g/mol
Synonyms	AG 1024; Tyrphostin AG 1024; 4-(3-Bromophenyl)-2-(4-nitrophenyl)-5H-pyrrolo[3,2-d]pyrimidin-5-one; 4-(3-Bromophenyl)-2-(4-nitrophenyl)-1H-pyrrolo[3,2-d]pyrimidin-5(4H)-one; IGF-1R/IR Inhibitor; Insulin-like growth factor 1 receptor inhibitor; Tyrphostin
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 1024 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.