Description

8-Quinolinesulfonyl Fluoride is a specialized organofluorine building block featuring a reactive sulfonyl fluoride group attached to a quinoline scaffold. This compound matters as a key intermediate for the synthesis of sulfonamide derivatives, which are crucial in medicinal chemistry and materials science. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing new drug candidates, particularly protease inhibitors, and for creating advanced functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of biologically active sulfonamide compounds, including potential protease inhibitors and other therapeutic agents.
• Chemical Biology Probe Development: Used in activity-based protein profiling (ABPP) and covalent inhibitor design due to the reactivity of the sulfonyl fluoride group with specific amino acid residues.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides and pesticides with sulfonamide functionalities.
• Polymer & Materials Science: Employed in the synthesis of functional monomers and polymers, such as sulfonated materials for ion-exchange membranes or specialty coatings.
• Organic Synthesis Reagent: Utilized in palladium-catalyzed cross-coupling reactions and other transformations to introduce the quinoline-sulfonyl moiety into complex molecules.

Basic Information

Product Name	8-Quinolinesulfonyl Fluoride
CAS No.	65433-98-9
Molecular Formula	C9H6FNO2S
Molecular Weight	211.21 g/mol
Synonyms	Quinoline-8-sulfonyl fluoride; 8-Sulfonylfluoride quinoline; 8-Quinolylsulfonyl fluoride; 8-Fluorosulfonylquinoline; 1-Azanaphthalene-8-sulfonyl fluoride; 8-Quinolinesulfonylfluoride; 8-QSF
EINECS	Contact for details

Quality Control

Our 8-Quinolinesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.