Description

4-Pyridinecarbonyl Chloride, 2-Fluoro- (9Ci) is a high-purity, reactive fluorinated heterocyclic building block. This compound is critical for introducing the 2-fluoropyridine-4-carbonyl moiety into target molecules, enabling precise structural modifications in advanced synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluoropyridine scaffold enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses (CROs/CMOs) producing complex, fluorinated organic molecules for client projects.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.

Basic Information

Product Name	4-Pyridinecarbonyl Chloride, 2-Fluoro- (9Ci)
CAS No.	65352-95-6
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	2-Fluoropyridine-4-carbonyl chloride; 2-Fluoroisonicotinoyl chloride; 2-Fluoro-4-pyridinecarbonyl chloride; 4-Carboxy-2-fluoropyridine chloride; 2-Fluoropyridine-4-carboxylic acid chloride; Isonicotinoyl chloride, 2-fluoro-; 2-Fluoroisonicotinic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Pyridinecarbonyl Chloride, 2-Fluoro- (9Ci) is produced and analyzed under strict quality management protocols. We ensure high lot-to-lot consistency through comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) providing full specification results is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.