Description

3-Pyridinecarbonyl Chloride, 6-Fluoro- (9Ci) is a high-purity fluorinated heterocyclic acid chloride building block. This compound is critical for introducing the 6-fluoro-3-pyridinoyl moiety into target molecules, enabling precise structural modifications. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including kinase inhibitors and other biologically relevant compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and central nervous system (CNS) active agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances bioavailability and stability.
• Chemical Research: Serves as a versatile reagent in organic synthesis for constructing complex pyridine-based scaffolds in academic and industrial R&D.
• Material Science: Potential precursor for creating functionalized ligands and monomers used in advanced polymeric materials.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring fluoropyridine chemistry.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 6-Fluoro- (9Ci)
CAS No.	65352-94-5
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	6-Fluoronicotinoyl Chloride; 6-Fluoropyridine-3-carbonyl Chloride; 6-Fluoro-3-pyridinecarboxylic Acid Chloride; 6-Fluoronicotinic Acid Chloride; 6-Fluoro-3-pyridinylcarbonyl Chloride; 6-Fluoronicotinyl Chloride; 3-Carbonyl Chloride-6-fluoropyridine
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Chloride, 6-Fluoro- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and GC-MS results, to verify identity and purity. A Certificate of Analysis (COA) is supplied with each shipment, and our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.