Description

Phenylalanyl-Alanyl-Arginine Chloromethyl Ketone is a synthetic peptide-based irreversible protease inhibitor, specifically designed to target enzymes with trypsin-like specificity. This compound matters for its high selectivity and potency in biochemical research and pharmaceutical development, serving as a critical tool for studying protease mechanisms and pathways. It is primarily needed by researchers and manufacturers in the life sciences, pharmaceutical R&D, and biotechnology sectors for enzyme inhibition studies and drug discovery programs.

Application

• Biochemical research as a specific, irreversible inhibitor of trypsin-like serine proteases.
• Pharmaceutical R&D for studying protease-related disease mechanisms and validating drug targets.
• Proteomics and enzymology studies to understand enzyme kinetics and inhibition profiles.
• Development of diagnostic assays and kits that require controlled protease activity.
• Cell biology research to investigate the role of specific proteases in cellular processes.
• Production of high-purity reference standards for analytical and quality control purposes.

Basic Information

Product Name	Phenylalanyl-Alanyl-Arginine Chloromethyl Ketone
CAS No.	65319-55-3
Molecular Formula	C22H34ClN7O4
Molecular Weight	496.00 g/mol
Synonyms	Phe-Ala-Arg-CH2Cl; FAK-CMK; Benzyloxycarbonyl-Phe-Ala-Arg-chloromethyl ketone; Z-FAK-CMK; Chloromethyl ketone inhibitor of trypsin; Protease Inhibitor 65319-55-3; TPCK-related inhibitor; N-α-CBZ-Phenylalanyl-Alanyl-Arginine Chloromethyl Ketone
EINECS	Contact for details

Quality Control

Our Phenylalanyl-Alanyl-Arginine Chloromethyl Ketone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.