Description

Piperidine, 4,4-Difluoro-1-(Trifluoroacetyl)- (9Ci) is a high-value, fluorinated piperidine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both difluoro and trifluoroacetyl substituents, makes it an essential building block for introducing fluorine motifs into complex molecules, which is a key strategy for modulating their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by specialty chemical manufacturers.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for incorporating fluorinated piperidine scaffolds which can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved lipophilicity, membrane penetration, and environmental persistence of the active ingredient.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and other sophisticated chemical transformations.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty materials with unique surface properties, thermal stability, or chemical resistance.
• Fluorine Chemistry Building Block: A versatile starting material for further functionalization in medicinal and process chemistry to create a diverse array of fluorinated compounds.

Basic Information

Item	Detail
Product Name	Piperidine, 4,4-Difluoro-1-(Trifluoroacetyl)- (9Ci)
CAS No.	65220-85-1
Molecular Formula	C7H6F5NO
Molecular Weight	215.12 g/mol
Synonyms	4,4-Difluoro-1-(trifluoroacetyl)piperidine; 1-(Trifluoroacetyl)-4,4-difluoropiperidine; 4,4-Difluoro-N-(trifluoroacetyl)piperidine; 4,4-Difluoropiperidine-1-carboxylic acid trifluoromethyl ester; 65220-85-1; 1-Trifluoroacetyl-4,4-difluoropiperidine; 4,4-Difluoro-1-piperidinecarboxylic acid trifluoromethyl ester
EINECS	Contact for details

Quality Control

Every batch of Piperidine, 4,4-Difluoro-1-(Trifluoroacetyl)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.