Description

Meosuc-Ala-Ala-Pro-Val-Chloromethylketone is a specialized peptide chloromethyl ketone derivative, a potent and irreversible inhibitor of serine proteases. This compound is critical for biochemical research and pharmaceutical development, offering high selectivity and reactivity for enzyme active sites. It is primarily utilized by research institutions and pharmaceutical companies engaged in protease mechanism studies, inhibitor design, and drug discovery programs.

Application

• Biochemical Research: As a specific active-site directed inhibitor for studying the structure, function, and kinetics of serine proteases like elastase.
• Pharmaceutical Development: A key intermediate or tool compound in the design and synthesis of novel therapeutic protease inhibitors.
• Enzymology Studies: Used to elucidate catalytic mechanisms and define the substrate specificity pockets of target enzymes.
• Protease Profiling: Employed in activity-based protein profiling (ABPP) to identify and characterize protease activities in complex biological samples.
• Medicinal Chemistry: Serves as a scaffold for developing more potent and selective drug candidates targeting inflammatory and immune-related pathways.

Basic Information

Product Name	Meosuc-Ala-Ala-Pro-Val-Chloromethylketone
CAS No.	65144-34-5
Molecular Formula	C20H31ClN4O7
Molecular Weight	475.93 g/mol
Synonyms	MeOSuc-AAPV-CMK; Methoxysuccinyl-Ala-Ala-Pro-Val-Chloromethyl Ketone; N-Methoxysuccinyl-Alanyl-Alanyl-Prolyl-Valyl Chloromethyl Ketone; Elastase Inhibitor I, MeOSuc-AAPV-CMK; Protease Inhibitor (Elastase); AAPV-CMK; Suc-AAPV-CMK; N-(Methoxycarbonyl)alanylalanylprolylvaline chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Meosuc-Ala-Ala-Pro-Val-Chloromethylketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.