Description

Succinyl-Alanyl-Alanyl-Prolyl-Valine Chloromethyl Ketone is a specialized peptide-based irreversible inhibitor designed to target serine proteases. This compound matters for researchers and developers requiring precise, mechanism-based enzyme inhibition in biochemical and pharmaceutical studies. It is primarily needed by professionals in pharmaceutical R&D, proteomics research, and biochemical assay development for investigating enzyme function and developing therapeutic agents.

Application

• Biochemical Research: Used as a potent and selective active-site titrant and irreversible inhibitor for studying serine protease kinetics and mechanisms.
• Pharmaceutical Development: Serves as a key tool compound in the discovery and validation of novel protease-targeted drugs, particularly for conditions involving dysregulated proteolytic activity.
• Proteomics & Enzyme Characterization: Essential for identifying and characterizing specific protease activities within complex biological samples and pathways.
• Diagnostic Reagent Manufacturing: Employed in the formulation of specific enzyme activity assays and diagnostic kits that require controlled inhibition.
• Academic Research: A critical reagent in university and institutional labs for fundamental studies in enzymology, cell signaling, and protein biochemistry.

Basic Information

Product Name	Succinyl-Alanyl-Alanyl-Prolyl-Valine Chloromethyl Ketone
CAS No.	65144-33-4
Molecular Formula	C24H38N5O8Cl
Molecular Weight	560.04 g/mol
Synonyms	Suc-AAPV-CMK; Succinyl-AAPV-Chloromethyl Ketone; Suc-Ala-Ala-Pro-Val-CH2Cl; Suc-AAPV-CK; Protease Inhibitor Suc-AAPV-CMK; AAPV Chloromethyl Ketone, Succinyl-; N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Succinyl-Alanyl-Alanyl-Prolyl-Valine Chloromethyl Ketone is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous quality testing, including HPLC for purity verification and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and activity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.