Description

Glutamyl-Glycyl-Arginine Chloromethyl Ketone is a synthetic tripeptide derivative designed as a potent and irreversible serine protease inhibitor. This compound is of significant value in biochemical and pharmacological research for its ability to selectively inhibit specific proteolytic enzymes, enabling the study of protease function and signaling pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on enzymology, inflammation, and coagulation studies.

Application

• Biochemical Research: Used as a critical tool compound for studying the mechanism and inhibition of serine proteases like thrombin, trypsin, and related enzymes.
• Pharmaceutical Development: Serves as a reference standard and a key intermediate in the development of novel therapeutic agents targeting protease-driven diseases.
• Diagnostic Reagent Formulation: Employed in the development of specialized diagnostic assays and kits that require controlled protease activity.
• Enzyme Characterization: Facilitates the kinetic and structural characterization of proteases to understand substrate specificity and catalytic mechanisms.
• Cell Biology Studies: Applied in cellular models to investigate the role of specific proteases in processes such as apoptosis, inflammation, and cell signaling.

Basic Information

Product Name	Glutamyl-Glycyl-Arginine Chloromethyl Ketone
CAS No.	65113-67-9
Molecular Formula	C17H31ClN8O6
Molecular Weight	478.93 g/mol
Synonyms	Glu-Gly-Arg-CH2Cl; EGR-chloromethyl ketone; Glutamylglycylarginine chloromethyl ketone; Protease Inhibitor EGR-CK; (2S)-5-[[(2S)-1-[[(2S)-5-Amino-1-[[3-chloro-2-oxopropyl]amino]-1-oxopentan-2-yl]amino]-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]amino]-5-oxopentanoic acid; Acetyl-Glu-Gly-Arg-CH2Cl (common abbreviation); Serine protease inhibitor 65113-67-9
EINECS	Contact for details

Quality Control

Our Glutamyl-Glycyl-Arginine Chloromethyl Ketone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.