Description

Desipramine-D3 Hcl is a deuterium-labeled analog of the tricyclic antidepressant desipramine hydrochloride, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise and traceable reference materials.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of desipramine in biological matrices (plasma, serum, urine) during drug metabolism and pharmacokinetic (DMPK) studies.
• Pharmaceutical R&D: Used in method development and validation for the analysis of desipramine and related compounds in drug formulations and stability testing.
• Forensic Toxicology: Serves as a critical reference standard in the confirmation and quantification of desipramine in forensic samples for legal and medical investigations.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) in studies investigating the efficacy, safety, and optimal dosing of tricyclic antidepressants.
• Metabolite Identification: Aids in the identification and characterization of desipramine metabolites in in vitro and in vivo studies due to its isotopic label.
• Quality Control & Assurance: Employed by manufacturers of active pharmaceutical ingredients (APIs) and finished dosage forms to ensure batch-to-batch consistency and purity.

Basic Information

Product Name	Desipramine-D3 Hcl
CAS No.	65100-44-9
Molecular Formula	C18H19D3N2•HCl
Molecular Weight	305.85 g/mol
Synonyms	Desipramine-d3 hydrochloride; Norimipramine-d3 hydrochloride; 10,11-Dihydro-5-[3-(methylamino-d3)propyl]-5H-dibenz[b,f]azepine hydrochloride; 3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)-N-methyl-d3-propan-1-amine hydrochloride; DMI-d3 HCl; Desmethylimipramine-d3 HCl
EINECS	Contact for details

Quality Control

Every batch of Desipramine-D3 Hcl is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic purity (D-enrichment), chemical purity (by HPLC), and confirmation of structure. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.