Description

Per(6-Amino-6-Deoxy)β-Cyclodextrin Hydrochloride is a chemically modified cyclodextrin derivative where each primary hydroxyl group on the glucose units is substituted with an amino functionality, presented as its hydrochloride salt. This modification is critical as it imparts a cationic charge and enhanced water solubility, making it a powerful molecular encapsulation and complexation agent. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications requiring selective binding, chiral separation, or solubility enhancement of active compounds.

Application

• Pharmaceutical Formulation & Drug Delivery: Acts as a functional excipient to improve the solubility, stability, and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
• Chiral Separation & Analysis: Serves as a chiral selector or stationary phase modifier in capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) for the resolution of enantiomers.
• Catalysis & Organic Synthesis: Used as a supramolecular catalyst or host to facilitate specific chemical reactions within its hydrophobic cavity under mild conditions.
• Gene Delivery & Transfection: Explored as a component in non-viral gene delivery vectors due to its ability to complex with nucleic acids and facilitate cellular uptake.
• Sensor Development & Diagnostics: Incorporated into chemical sensors and biosensors for the selective recognition and detection of specific guest molecules.
• Cosmetic & Personal Care: Employed to stabilize and control the release of fragrances, vitamins, or other active ingredients in cosmetic formulations.

Basic Information

Item	Details
Product Name	Per(6-Amino-6-Deoxy)β-Cyclodextrin Hydrochloride
CAS No.	65024-90-0
Molecular Formula	C42H84N7O28 • xHCl
Molecular Weight	~1435.1 g/mol (base), Contact for exact salt form weight.
Synonyms	Heptakis(6-amino-6-deoxy)-β-cyclodextrin hydrochloride; 6A,6B,6C,6D,6E,6F,6G-Heptaamino-6A,6B,6C,6D,6E,6F,6G-heptadeoxy-β-cyclodextrin hydrochloride; Fully aminated β-cyclodextrin HCl; β-CD-NH2•HCl; Per-6-amino-β-cyclodextrin HCl; Amino-β-cyclodextrin, per-substituted hydrochloride
EINECS	Contact for details

Quality Control

Our Per(6-Amino-6-Deoxy)β-Cyclodextrin Hydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with key parameters such as assay, substitution degree, and impurity profile. Specifications can be aligned with research or cGMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Substitution (NMR/Titration)	6.8 - 7.2
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
pH (1% Solution)	3.0 - 5.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.