Description

Ng,Ng'-Dimethyl-L-Arginine, Dihydrochloride is a high-purity, chemically modified derivative of the essential amino acid L-arginine. This compound is a critical biochemical reagent and building block, valued for its role in modulating nitric oxide synthase (NOS) activity and studying cellular signaling pathways. It is primarily sought by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, biochemical research, and the development of diagnostic tools.

Application

• Biochemical Research: Used as a standard or reference compound in studies of nitric oxide (NO) metabolism, enzyme kinetics, and methylation processes.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor or active pharmaceutical ingredient (API) intermediate in the development of cardiovascular and neurological therapeutics.
• Cell Culture & In Vitro Studies: Employed in cell-based assays to investigate the role of asymmetric dimethylarginine (ADMA) and related pathways in disease models.
• Diagnostic Reagent Manufacturing: A vital component in the formulation of ELISA kits, clinical assay calibrators, and other diagnostic reagents for measuring ADMA levels.
• Metabolomics & Proteomics: Utilized as an internal standard or metabolite in mass spectrometry-based analyses for accurate quantification in biological samples.

Basic Information

Product Name	Ng,Ng'-Dimethyl-L-Arginine, Dihydrochloride
CAS No.	65005-57-4
Molecular Formula	C8H20N4O2 · 2HCl
Molecular Weight	285.19 g/mol (Free base: 202.26)
Synonyms	Asymmetric Dimethylarginine Dihydrochloride; ADMA·2HCl; L-NG,NG-Dimethylarginine Dihydrochloride; N(G),N(G)-Dimethyl-L-arginine Dihydrochloride; (2S)-2-Amino-5-[(amino-dimethylaminomethylene)amino]pentanoic acid dihydrochloride; H-Arg(Me2)-OH·2HCl; SDMA (Symmetric Dimethylarginine) isomer
EINECS	Contact for details

Quality Control

Our Ng,Ng'-Dimethyl-L-Arginine, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and production. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: + Specific value
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.