Description

4-(Bromomethyl)-2-Fluoropyridine is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a fluorine substituent on the pyridine ring, makes it indispensable for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce the pyridine moiety.
• Bioconjugation and Probe Synthesis: Useful for labeling biomolecules or creating fluorescent probes and diagnostic agents in life science research.

Basic Information

Product Name	4-(Bromomethyl)-2-Fluoropyridine
CAS No.	64992-03-6
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	2-Fluoro-4-(bromomethyl)pyridine; 4-(Bromomethyl)-2-fluoropyridine; 2-Fluoro-4-pyridinemethanol, bromo derivative; (2-Fluoropyridin-4-yl)methyl bromide; 4-Bromomethyl-2-fluoropyridine; 2-Fluoro-4-bromomethylpyridine; Pyridine, 4-(bromomethyl)-2-fluoro-
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-2-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles against our stringent specifications. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.