Description

Pifithrin-μ CAS NO 64984-31-2 is a potent and selective small-molecule inhibitor of p53-mediated apoptosis and transcriptional activity. This compound is a critical research tool for studying cellular stress responses, DNA damage pathways, and mechanisms of programmed cell death. It is primarily utilized by researchers and scientists in the fields of oncology, neurobiology, and pharmacology to investigate p53-dependent signaling and explore potential therapeutic interventions.

Application

• Biomedical Research: A key reagent for investigating the role of p53 in apoptosis, cell cycle arrest, and senescence in various in vitro and in vivo models.
• Oncology Studies: Used to protect normal cells from p53-dependent apoptosis induced by chemotherapy or radiation, helping to delineate mechanisms of cancer treatment toxicity and resistance.
• Neuroprotection Research: Employed in studies of neurodegenerative diseases and ischemic injury to examine the contribution of p53 to neuronal cell death.
• Cardioprotection Studies: Applied in research models to assess the inhibition of p53 in reducing myocardial cell death following ischemic events.
• Drug Discovery & Development: Serves as a pharmacological tool for validating p53 as a drug target and for screening novel therapeutic compounds.
• Stem Cell Research: Utilized to enhance the survival of stem cells under conditions of genotoxic stress during manipulation and expansion.

Basic Information

Product Name	Pifithrin-μ
CAS No.	64984-31-2
Molecular Formula	C16H17N3O2S
Molecular Weight	315.39 g/mol
Synonyms	Pifithrin-μ; PFTμ; 2-Phenylethynesulfonamide; Pifithrin-mu; p53 Inhibitor Pifithrin-μ; PFT-μ; NSC 303580; 1-(4-Methylphenyl)-2-(4-nitrophenyl)ethyne-1-sulfonamide
EINECS	Contact for details

Quality Control

Our Pifithrin-μ is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided to guarantee reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.