Description

(3E,5E)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester is a high-purity synthetic prostaglandin analog, a key intermediate in advanced pharmaceutical research and development. Its complex stereochemistry and functional groups make it an essential building block for creating novel therapeutic agents targeting specific biological pathways. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of prostaglandin-based drugs, where precise molecular structure and high purity are critical for efficacy and safety studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced prostaglandin and prostacyclin analogs for clinical research.
• Biochemical Research: Used as a reference standard or tool compound in studies investigating prostaglandin receptor (e.g., EP, IP receptors) signaling and function.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies aimed at developing new anti-inflammatory, cardiovascular, or ocular therapeutics.
• Process Development: Employed in the optimization and scale-up of synthetic routes for prostaglandin-based Active Pharmaceutical Ingredients (APIs).
• Analytical Standard: Used in HPLC, LC-MS, or NMR for method development, validation, and quality control of related pharmaceutical compounds.

Basic Information

Product Name	(3E,5E)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester
CAS No.	64812-79-9
Molecular Formula	C23H29ClO6
Molecular Weight	436.93 g/mol
Synonyms	Methyl (3E,5E)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hepta-3,5-dienoate; 9-Deoxy-9-methylene-16-phenoxy-17,18,19,20-tetranor-PGE2 methyl ester analog; Prostaglandin E2 (PGE2) methyl ester derivative; 16-(3-Chlorophenoxy)-tetranor-PGE2 methyl ester; 64812-79-9; UNII-9H8L8L3L2T; Prostanoid intermediate
EINECS	Contact for details

Quality Control

Every batch of our (3E,5E)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.