Description

(3Z,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester is a high-purity synthetic prostaglandin analog with a complex stereochemistry that is critical for its biological activity. This compound serves as a key advanced intermediate in the pharmaceutical synthesis of prostaglandin-based therapeutics, where precise molecular structure dictates efficacy. It is essential for research and development laboratories and production facilities focused on cardiovascular, ocular, and anti-inflammatory drug candidates.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of prostaglandin E1 (PGE1) analogs like alprostadil.
• Cardiovascular Research: Used in R&D for developing vasodilatory agents to treat conditions like peripheral vascular disease.
• Ophthalmic Drug Development: Serves as a precursor for prostaglandin analogs used in glaucoma treatment to reduce intraocular pressure.
• Biochemical Research: A valuable tool for studying prostaglandin receptors, signal transduction pathways, and inflammatory responses in vitro.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for clinical trial material and commercial API manufacturing.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(3Z,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester
CAS No.	64775-52-6
Molecular Formula	C23H29ClO6
Molecular Weight	436.93 g/mol
Synonyms	Alprostadil Methyl Ester Intermediate; PGE1 Methyl Ester Derivative; 11-Deoxy-16-phenoxy-17,18,19,20-tetranor PGE1 Methyl Ester; (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoic Acid Methyl Ester; 16-Phenoxy Tetranor Prostaglandin E1 Methyl Ester; Prostaglandin E1 Methyl Ester Analog; 64775-52-6; Methyl (3Z,5Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hepta-3,5-dienoate
EINECS	Contact for details

Quality Control

Every batch of our (3Z,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-3,5-Heptadienoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing assay, related substances, and chiral purity is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.