Description

7-Cysteinyldehydroretronecine is a specialized pyrrolizidine alkaloid derivative, a key intermediate in the study of hepatotoxic compounds. This compound matters for its critical role in biochemical research, particularly in the investigation of metabolic pathways and the formation of DNA adducts related to liver toxicity. It is primarily needed by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on toxicology, phytochemistry, and the safety assessment of herbal products and food supplements.

Application

• Biochemical Research Intermediate: Serves as a crucial reference standard and synthetic precursor in the study of pyrrolizidine alkaloid metabolism and toxicity.
• Toxicology Studies: Used in in vitro and in vivo models to investigate mechanisms of hepatotoxicity and genotoxicity.
• Analytical Reference Standard: Essential for the development and validation of analytical methods (HPLC, LC-MS) for detecting and quantifying pyrrolizidine alkaloids and their metabolites in complex matrices.
• Phytochemistry and Natural Product Research: Employed in the isolation, identification, and characterization of related alkaloids from plant sources.
• Food and Herbal Supplement Safety: Supports contamination screening and risk assessment programs to ensure product safety and regulatory compliance.
• Metabolite Synthesis: Used in the chemical synthesis of specific metabolites for further biological activity and pharmacokinetic studies.

Basic Information

Product Name	7-Cysteinyldehydroretronecine
CAS No.	64660-85-1
Molecular Formula	C10H16N2O3S
Molecular Weight	244.31 g/mol
Synonyms	7-Cysteinyldehydroretronecine; 7-[(2R)-2-Amino-2-carboxyethyl]-1,2-didehydro-7,8-didehydroretronecine; 7-S-Cysteinyldehydroretronecine; Dehydroretronecine 7-cysteine adduct; (R)-2-Amino-3-((1-hydroxy-6,7-didehydro-5H-pyrrolizin-7-yl)thio)propanoic acid; PA metabolite reference standard
EINECS	Contact for details

Quality Control

Our 7-Cysteinyldehydroretronecine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.