Description

14,15-Dihydroforskolin is a semi-synthetic derivative of the natural diterpene forskolin, characterized by its saturated C14-C15 bond. This modification enhances its stability and makes it a valuable reference standard and research compound for studying adenylate cyclase activity and cyclic AMP (cAMP) signaling pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for biochemical research, assay development, and as a critical analytical standard.

Application

• Biochemical Research: Used as a key tool compound to investigate cAMP-mediated signal transduction and adenylate cyclase activation mechanisms.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in drug development, particularly for forskolin-related compounds.
• Cell Biology Studies: Employed in in vitro studies to modulate intracellular cAMP levels, aiding research in cardiovascular, metabolic, and neurological systems.
• Enzyme Assay Development: Acts as a stable control or substrate in high-throughput screening (HTS) assays targeting adenylate cyclase.
• Academic Research: Utilized in university and institutional labs for fundamental research in molecular pharmacology and cellular signaling.

Basic Information

Product Name	14,15-Dihydroforskolin
CAS No.	64657-24-5
Molecular Formula	C22H34O7
Molecular Weight	410.50 g/mol
Synonyms	7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one; Dihydroforskolin; 14,15-Dihydro-7-deacetylforskolin; 1α,6β,9α-Trihydroxy-8,13-epoxy-labd-14-en-11-one 7-acetate; Coleonol B derivative
EINECS	Contact for details

Quality Control

Our 14,15-Dihydroforskolin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.